| http://purl.uniprot.org/citations/17360653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17360653 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs)-2 and -4 are important proteins in innate immunity, recognizing microbial products and eliciting host defense responses. Both use the adapter proteins MyD88 and MyD88 adapter-like (Mal) to activate signaling pathways. Here we report that Mal but not MyD88 interacts with caspase-1, the enzyme that processes the precursors of the proinflammatory cytokines IL-1beta and IL-18. The interaction was found in a yeast two-hybrid screen and was confirmed by reciprocal GST pull-downs and coimmunoprecipitation of endogenous proteins. We were unable to implicate Mal in regulating caspase-1 activation. However, we found that Mal was cleaved by caspase-1 and that inhibition of caspase-1 activity blocked TLR2- and TLR4-mediated NF-kappaB and p38 MAP kinase activation but not IL-1 or TLR7 signaling, which are Mal independent. These responses, and the induction of TNF, were also attenuated in caspase-1-deficient cells. Finally, unlike wild-type Mal, a mutant Mal, which was not cleaved by caspase-1, was unable to signal and acted as a dominant negative inhibitor of TLR2 and TLR4 signaling. Our study therefore reveals a role for caspase-1 in the regulation of TLR2 and TLR4 signaling pathways via an effect on Mal. This functional interaction reveals an important aspect of the coordination between TLRs and caspase-1 during the innate response to pathogens."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0608100104"xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Murphy C."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "O'Neill L.A."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Yamamoto M."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Akira S."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Rothwell N."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Golenbock D."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Miggin S.M."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Moynagh P."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Dunne A."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Jefferies C."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Pinteaux E."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Banahan K."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/author | "Palsson-McDermott E."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/pages | "3372-3377"xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/title | "NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1."xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17360653 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17360653 |
| http://purl.uniprot.org/citations/17360653 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17360653 |
| http://purl.uniprot.org/uniprot/#_A8K249-mappedCitation-17360653 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17360653 |