| http://purl.uniprot.org/citations/17360776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17360776 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17360776 | http://www.w3.org/2000/01/rdf-schema#comment | "The Mesp2 transcription factor plays essential roles in segmental border formation and in the establishment of rostro-caudal patterning within a somite. A possible Mesp2 target gene, Ripply2, was identified by microarray as being downregulated in the Mesp2-null mouse. Ripply2 encodes a putative transcriptional co-repressor containing a WRPW motif. We find that Mesp2 binds to the Ripply2 gene enhancer, indicating that Ripply2 is a direct target of Mesp2. We then examined whether Ripply2 is responsible for the repression of genes under the control of Mesp2 by generating a Ripply2-knockout mouse. Unexpectedly, Ripply2-null embryos show a rostralized phenotype, in contrast to Mesp2-null mice. Gene expression studies together with genetic analyses further revealed that Ripply2 is a negative regulator of Mesp2 and that the loss of the Ripply2 gene results in the prolonged expression of Mesp2, leading to a rostralized phenotype via the suppression of Notch signaling. Our study demonstrates that a Ripply2-Mesp2 negative-feedback loop is essential for the periodic generation of the rostro-caudal polarity within a somite."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.000836"xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.000836"xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Igarashi K."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Igarashi K."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Sasaki N."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Sasaki N."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Saga Y."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Saga Y."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Kiso M."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Kiso M."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Morimoto M."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Morimoto M."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Kanno J."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Kanno J."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Oginuma M."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Oginuma M."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Aizaki K."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/author | "Aizaki K."xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/17360776 | http://purl.uniprot.org/core/name | "Development"xsd:string |