| http://purl.uniprot.org/citations/17360941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17360941 | http://www.w3.org/2000/01/rdf-schema#comment | "Activated tyrosine kinases have been frequently implicated in the pathogenesis of cancer, including acute myeloid leukemia (AML), and are validated targets for therapeutic intervention with small-molecule kinase inhibitors. To identify novel activated tyrosine kinases in AML, we used a discovery platform consisting of immunoaffinity profiling coupled to mass spectrometry that identifies large numbers of tyrosine-phosphorylated proteins, including active kinases. This method revealed the presence of an activated colony-stimulating factor 1 receptor (CSF1R) kinase in the acute megakaryoblastic leukemia (AMKL) cell line MKPL-1. Further studies using siRNA and a small-molecule inhibitor showed that CSF1R is essential for the growth and survival of MKPL-1 cells. DNA sequence analysis of cDNA generated by 5'RACE from CSF1R coding sequences identified a novel fusion of the RNA binding motif 6 (RBM6) gene to CSF1R gene generated presumably by a t(3;5)(p21;q33) translocation. Expression of the RBM6-CSF1R fusion protein conferred interleukin-3 (IL-3)-independent growth in BaF3 cells, and induces a myeloid proliferative disease (MPD) with features of megakaryoblastic leukemia in a murine transplant model. These findings identify a novel potential therapeutic target in leukemogenesis, and demonstrate the utility of phosphoproteomic strategies for discovery of tyrosine kinase alleles."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-10-052282"xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Daibata M."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Lee K."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Rush J."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Polakiewicz R.D."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Reeves C."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Druker B.J."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Goss V.L."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Gilliland D.G."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Tyner J.W."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Mercher T."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Heinrich M.C."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Miyoshi I."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Popova L."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Walters D.K."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Gu T.L."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/author | "Cornejo M.G."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/pages | "323-333"xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/title | "A novel fusion of RBM6 to CSF1R in acute megakaryoblastic leukemia."xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/17360941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17360941 |