| http://purl.uniprot.org/citations/17363730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17363730 | http://www.w3.org/2000/01/rdf-schema#comment | "Toll-like receptors (TLRs) and complement are 2 components of innate immunity that are critical for first-line host defense and elicitation of adaptive immune responses. Many pathogen-associated molecular patterns activate both TLR and complement, but whether and how these 2 systems, when coactivated in vivo, interact with each other has not been well studied. We demonstrate here a widespread regulation of TLR signaling by complement in vivo. The TLR ligands lipopolysacharride (TLR4), zymosan (TLR2/6), and CpG oligonucleotide (TLR9) caused, in a complement-dependent manner, strikingly elevated plasma interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and IL-1beta, and/or decreased plasma IL-12 levels in mice deficient in the membrane complement inhibitor decay-accelerating factor (DAF). A similar outcome was observed in wild-type mice cotreated with the TLR ligands and cobra venom factor, a potent complement activator. The regulatory effect of complement on TLR-induced cytokine production in vivo was mediated by the anaphylatoxin receptors C5aR and C3aR. Additionally, changes in lipopolysaccharide (LPS)-induced cytokine production in DAF-deficient mice correlated with increased mitogen-activated protein kinase and nuclear factor-kappaB activation in the spleen. These results reveal a strong interaction between complement and TLR signaling in vivo and suggest a novel mechanism by which complement promotes inflammation and modulates adaptive immunity."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-12-063636"xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Kimura Y."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Fang C."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Miwa T."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Lambris J.D."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Wetsel R.A."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Song W.C."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/author | "Sfyroera G."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/pages | "228-236"xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/title | "Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo."xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/17363730 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17363730 |
| http://purl.uniprot.org/citations/17363730 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17363730 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-17363730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17363730 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-17363730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17363730 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT01-mappedCitation-17363730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17363730 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-17363730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17363730 |
| http://purl.uniprot.org/uniprot/#_A2BI31-mappedCitation-17363730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17363730 |
| http://purl.uniprot.org/uniprot/#_E1APH6-mappedCitation-17363730 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17363730 |