| http://purl.uniprot.org/citations/17363735 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17363735 | http://www.w3.org/2000/01/rdf-schema#comment | "X-linked severe combined immunodeficiency (SCID-X1) results from mutations in the IL2RG gene, which encodes the common gamma chain (gammac) of the receptors for interleukin (IL)-2, 4, 7, 9, 15, and 21. Affected infants typically lack T and natural killer (NK) cells as a consequence of loss of signaling via the IL-7 receptor (IL-7R) and the IL-15R, respectively. In some infants, however, autologous NK cells are observed despite failure of T-cell ontogeny. The mechanisms by which mutations in gammac differentially impact T- and NK-cell ontogeny remain incompletely understood. We used SCID-X1 patient-derived EBV-transformed B cells to test the hypothesis that the IL-15R-mediated signaling is preferentially retained as gammac expression becomes limiting. Signal transduction via the IL-15R was readily detected in control EBV-transformed B cells, and via the IL-7R when modified to express IL-7Ralpha. Under the same experimental conditions, patient-derived EBV-transformed B cells expressing trace amounts of gammac proved incapable of signal transduction via the IL-7R while retaining the capacity for signal transduction via the IL-15R. An equivalent result was obtained in ED-7R cells modified to express varying levels of gammac. Collectively, these results confirm that signal transduction via the IL-15R, and hence NK ontogeny, is preferentially retained relative to the IL-7R as gammac expression becomes limiting."xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2006-11-055442"xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/author | "Alexander I.E."xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/author | "Ginn S.L."xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/author | "Logan G.J."xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/author | "Smyth C.M."xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/author | "Deakin C.T."xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/pages | "91-98"xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/title | "Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors."xsd:string |
| http://purl.uniprot.org/citations/17363735 | http://purl.uniprot.org/core/volume | "110"xsd:string |
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