| http://purl.uniprot.org/citations/17366632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17366632 | http://www.w3.org/2000/01/rdf-schema#comment | "The Forkhead Box m1 (Foxm1) transcription factor is expressed in cardiomyocytes and cardiac endothelial cells during heart development. In this study, we used a novel Foxm1 -/-mouse line to demonstrate that Foxm1-deletion causes ventricular hypoplasia and diminished DNA replication and mitosis in developing cardiomyocytes. Proliferation defects in Foxm1 -/-hearts were associated with a reduced expression of Cdk1-activator Cdc25B phosphatase and NFATc3 transcription factor, and with abnormal nuclear accumulation of the Cdk-inhibitor p21(Cip1) protein. Depletion of Foxm1 levels by siRNA caused altered expression of these genes in cultured HL-1 cardiomyocytes. Endothelial-specific deletion of the Foxm1 fl/fl allele in Tie2-Cre Foxm1 fl/fl embryos did not influence heart development and cardiomyocyte proliferation. Foxm1 protein binds to the -9,259/-9,288-bp region of the endogenous mouse NFATc3 promoter, indicating that Foxm1 is a transcriptional activator of the NFATc3 gene. Foxm1 regulates expression of genes essential for the proliferation of cardiomyocytes during heart development."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.org/dc/terms/identifier | "doi:10.1002/dvdy.21113"xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Costa R.H."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Ramakrishna S."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Qin Y."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Malik A.B."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Zhao Y.Y."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Kalinichenko V.V."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Wang I.C."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Malin D."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Petrovic V."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Kim I.M."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Ackerson T."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Kalin T.V."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/author | "Meliton L."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/name | "Dev Dyn"xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/pages | "1000-1013"xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/title | "Myocardium defects and ventricular hypoplasia in mice homozygous null for the Forkhead Box M1 transcription factor."xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://purl.uniprot.org/core/volume | "236"xsd:string |
| http://purl.uniprot.org/citations/17366632 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17366632 |
| http://purl.uniprot.org/citations/17366632 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17366632 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ11-mappedCitation-17366632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17366632 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MQJ3-mappedCitation-17366632 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17366632 |