| http://purl.uniprot.org/citations/17367514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17367514 | http://www.w3.org/2000/01/rdf-schema#comment | "The Kluyveromyces lactis zymocin complex kills Saccharomyces cerevisiae cells in a process that involves tRNA cleavage by its tRNAse gamma-toxin subunit. In contrast to the gamma-toxin mode of action, the early steps of the zymocin response are less well characterized. Here, we present high-dosage suppressors of zymocin that encode a putative Pkc1-related kinase (ISR1) and UDP-glucose pyrophosphorylase (UGPase) (UGP1). Anti-UGPase Western blots and GAL10 - ISR1 overexpression suggest that zymocin suppression correlates with overproduction of UGPase or Isr1. As judged from protection against exo-zymocin and unaltered sensitivity to endogenous gamma-toxin, high-copy ISR1 and UGP1 operate in early, nontarget steps of the zymocin pathway. Consistent with a recent report on in vitro phosphorylation of Isr1 and UGPase by the CDK Pho85, high-copy ISR1 and UGP1 suppression of zymocin is abolished in a pho85 null mutant lacking CDK activity of Pho85. Moreover, suppression requires UGPase enzyme activity, and ISR1 overexpression also protects against CFW, a chitin-interfering poison. Our data agree with roles for UGPase in cell wall biosynthetic processes and for Isr1 in Pkc1-related cell wall integrity. In sum, high-copy ISR1 and UGP1 cells affect early steps of the zymocin response and potentially prevent the lethal K. lactis killer complex from establishing cell surface recognition and/or contact."xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1567-1364.2007.00216.x"xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/author | "Mehlgarten C."xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/author | "Schaffrath R."xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/author | "Rutter J."xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/author | "Zink S."xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/name | "FEMS Yeast Res"xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/pages | "722-730"xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/title | "Dosage suppression of the Kluyveromyces lactis zymocin by Saccharomyces cerevisiae ISR1 and UGP1."xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://purl.uniprot.org/core/volume | "7"xsd:string |
| http://purl.uniprot.org/citations/17367514 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17367514 |
| http://purl.uniprot.org/citations/17367514 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17367514 |
| http://purl.uniprot.org/uniprot/#_A0A6A5PSL8-mappedCitation-17367514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/#_A0A6A5Q1L8-mappedCitation-17367514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/#_P34253-mappedCitation-17367514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/#_Q06098-mappedCitation-17367514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/#_P32861-mappedCitation-17367514 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/A0A6A5Q1L8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/Q06098 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/A0A6A5PSL8 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/P32861 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17367514 |
| http://purl.uniprot.org/uniprot/P34253 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17367514 |