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| http://purl.uniprot.org/citations/17367784 | http://www.w3.org/2000/01/rdf-schema#comment | "Cadmium is a toxic metal that initiates both mitogenic responses and cell death. We show that Cd(2+) increases phosphorylation and activity of Ca(2+)/calmodulin-dependent protein kinase II (CaMK-II) in mesangial cells, in a concentration-dependent manner. Activation is biphasic with peaks at 1-5 min and 4-6 h. Cadmium also activates Erk, but this appears to be independent of CaMK-II. At 10-20 microM, Cd(2+) initiates apoptosis in 25-55% of mesangial cells by 6h. Inhibition of CaMK-II, but not of Erk, suppresses Cd(2+)-induced apoptosis. We conclude that activation of CaMK-II by Cd(2+) contributes to apoptotic cell death, independent of Erk activation."xsd:string |
| http://purl.uniprot.org/citations/17367784 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2007.03.003"xsd:string |
| http://purl.uniprot.org/citations/17367784 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/17367784 | http://purl.uniprot.org/core/author | "Templeton D.M."xsd:string |
| http://purl.uniprot.org/citations/17367784 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17367784 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/17367784 | http://purl.uniprot.org/core/pages | "1481-1486"xsd:string |
| http://purl.uniprot.org/citations/17367784 | http://purl.uniprot.org/core/title | "Cadmium activates CaMK-II and initiates CaMK-II-dependent apoptosis in mesangial cells."xsd:string |
| http://purl.uniprot.org/citations/17367784 | http://purl.uniprot.org/core/volume | "581"xsd:string |
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