| http://purl.uniprot.org/citations/17368745 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17368745 | http://www.w3.org/2000/01/rdf-schema#comment | "Homing of hematopoietic stem/progenitor cells (HS/PC) to the bone marrow (BM) microenvironment is the first and essential step in HS/PC engraftment and initiation of the marrow reconstitution during clinical hematopoietic stem cell transplantation (HSCT). How to improve the homing efficiencies and make full use of HS/PC resources, especially umbilical cord blood (UCB), are of great importance in clinical practice. However, the cellular and molecular mechanisms that govern this process are poorly understood. Glycosylphosphatidylinositol-phospholipase D (GPI-PLD) is an enzyme which can regulate the expression of Glycosylphosphatidylinositol (GPI)-anchored proteins and modulate their correspondent functions by releasing GPI-anchored proteins from cell membrane. Recent studies suggested that the mechanisms of the malignancy and prognosis of certain tumors were correlated with GPI-PLD. HS/PC homing was similar to tumor invasion and metastasis in some process. Here we proposed the hypothesis that GPI-PLD might also has played a role in the homing of HS/PC by modulating the adhesion and migration of these cells. If GPI-PLD did participate in HS/PC homing, maybe the mechanisms of homing can herefrom be partly elucidated, which would benefit transplantation in clinical practice."xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mehy.2006.12.046"xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/author | "Chen F."xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/author | "Song K."xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/name | "Med Hypotheses"xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/pages | "660-665"xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/title | "How Glycosylphosphatidylinositol-phospholipase D acts in homing of hematopoietic stem/progenitor cells?"xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://purl.uniprot.org/core/volume | "69"xsd:string |
| http://purl.uniprot.org/citations/17368745 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17368745 |
| http://purl.uniprot.org/citations/17368745 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17368745 |
| http://purl.uniprot.org/uniprot/P80108#attribution-AA8C701793E6885F9C6DD7F65FCC51B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17368745 |