| http://purl.uniprot.org/citations/17371836 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17371836 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17371836 | http://www.w3.org/2000/01/rdf-schema#comment | "The RNA-binding protein Sam68 is involved in apoptosis, but its cellular mRNA targets and its mechanism of action remain unknown. We demonstrate that Sam68 binds the mRNA for Bcl-x and affects its alternative splicing. Depletion of Sam68 by RNA interference caused accumulation of antiapoptotic Bcl-x(L), whereas its up-regulation increased the levels of proapoptotic Bcl-x(s). Tyrosine phosphorylation of Sam68 by Fyn inverted this effect and favored the Bcl-x(L) splice site selection. A point mutation in the RNA-binding domain of Sam68 influenced its splicing activity and subnuclear localization. Moreover, coexpression of ASF/SF2 with Sam68, or fusion with an RS domain, counteracted Sam68 splicing activity toward Bcl-x. Finally, Sam68 interacted with heterogenous nuclear RNP (hnRNP) A1, and depletion of hnRNP A1 or mutations that impair this interaction attenuated Bcl-x(s) splicing. Our results indicate that Sam68 plays a role in the regulation of Bcl-x alternative splicing and that tyrosine phosphorylation of Sam68 by Src-like kinases can switch its role from proapoptotic to antiapoptotic in live cells."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200701005"xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200701005"xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Achsel T."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Achsel T."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Paronetto M.P."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Paronetto M.P."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Sette C."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Sette C."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Chalfant C.E."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Chalfant C.E."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Massiello A."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/author | "Massiello A."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/pages | "929-939"xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/pages | "929-939"xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/title | "The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/title | "The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x."xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/volume | "176"xsd:string |
| http://purl.uniprot.org/citations/17371836 | http://purl.uniprot.org/core/volume | "176"xsd:string |