| http://purl.uniprot.org/citations/17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17371977 | http://www.w3.org/2000/01/rdf-schema#comment | "TNF-alpha converting enzyme (TACE; ADAM17), a member of the ADAM (a disintegrin and metalloprotease) family of metalloproteases, has been shown to cleave a wide variety of cell surface proteins of immunological importance. Due to the broad expression of TACE and the early postnatal lethality of TACE-deficient mice, it has been difficult to assess the role of TACE in lymphocyte development. Indeed, it is not known whether hemopoietic and/or nonhemopoietic expression of TACE is required for normal lymphocyte development. In the current study, we analyzed the lymphoid system of tace(DeltaZn/DeltaZn) mice and tace(DeltaZn/DeltaZn) bone marrow RAG1(-/-) recipients. Our results clearly show that nonlymphocyte expression of TACE is required for normal lymphocyte development and lymphoid organ structure. Lack of TACE function resulted in a partial block in T cell development at the double-negative 4:double-positive transition in the thymus, a loss of B cell development/maturation in the spleen, and a lack of B cell follicle and germinal center formation in the spleen. Thus, TACE serves as a lymphocyte extrinsic factor that is essential for normal T development and peripheral B cell maturation."xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.178.7.4214"xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/author | "Dempsey P.J."xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/author | "Vignali D.A."xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/author | "Boyd K."xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/pages | "4214-4221"xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/title | "Non-cell autonomous expression of TNF-alpha-converting enzyme ADAM17 is required for normal lymphocyte development."xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://purl.uniprot.org/core/volume | "178"xsd:string |
| http://purl.uniprot.org/citations/17371977 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17371977 |
| http://purl.uniprot.org/citations/17371977 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17371977 |
| http://purl.uniprot.org/uniprot/Q9Z0F8#attribution-B191C3062C200118E2C3837231BA8AAD | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_A0A338P6F3-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_A0A338P6I8-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_B2RRI1-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_B2RRI4-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_E9PXU2-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_B7ZNJ0-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_J3QMF2-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_J3QNB3-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_Q3UV09-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |
| http://purl.uniprot.org/uniprot/#_Q3UNK7-mappedCitation-17371977 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17371977 |