| http://purl.uniprot.org/citations/17372034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17372034 | http://www.w3.org/2000/01/rdf-schema#comment | "Erythropoietin (EPO) fosters tissue oxygenation by stimulating erythropoiesis. More recently, EPO has been recognized as a tissue-protective cytokine. In this study, we tested the hypothesis that endothelial NO synthase (eNOS) plays a key role in the vascular protective effect of EPO. A murine model of wire-induced injury of carotid artery was used to examine the effect of EPO on endothelial repair and arterial wall architecture. Recombinant human EPO (1000 U/kg, SC, biweekly) was administered for 2 weeks in wild-type and eNOS-deficient mice after which reactivity of isolated carotid arteries was studied in vitro, and the vasculature was histologically assessed. Injured arteries exhibited impairment of endothelium-dependent relaxations to acetylcholine (P<0.05). This was associated with increased medial cross-sectional area (P<0.05). EPO upregulated expression of phosphorylated Ser1177-eNOS and normalized the vasodilator response to acetylcholine (P<0.05). Furthermore, EPO prevented the injury-induced increase in medial cross-sectional area (P<0.05). The vascular protective effects of EPO were abolished in eNOS-deficient mice. Most notably, EPO significantly increased systolic blood pressure and enhanced medial thickening of injured carotid arteries in eNOS-deficient mice (P<0.05). Our results demonstrate that EPO prevents aberrant remodeling of the injured carotid artery. The protective effects of EPO are critically dependent on activation of eNOS."xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.org/dc/terms/identifier | "doi:10.1161/hypertensionaha.106.085704"xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/author | "Smith L.A."xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/author | "Richardson D."xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/author | "Katusic Z.S."xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/author | "d'Uscio L.V."xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/author | "Nath K.A."xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/author | "Santhanam A.V."xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/name | "Hypertension"xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/pages | "1142-1148"xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/title | "Essential role of endothelial nitric oxide synthase in vascular effects of erythropoietin."xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/17372034 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17372034 |
| http://purl.uniprot.org/citations/17372034 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17372034 |
| http://purl.uniprot.org/uniprot/#_B7ZKK5-mappedCitation-17372034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17372034 |
| http://purl.uniprot.org/uniprot/#_G9JKG7-mappedCitation-17372034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17372034 |
| http://purl.uniprot.org/uniprot/#_T2DKX4-mappedCitation-17372034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17372034 |
| http://purl.uniprot.org/uniprot/#_P01588-mappedCitation-17372034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17372034 |
| http://purl.uniprot.org/uniprot/#_P70313-mappedCitation-17372034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17372034 |
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| http://purl.uniprot.org/uniprot/#_Q8C5P3-mappedCitation-17372034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17372034 |
| http://purl.uniprot.org/uniprot/#_Q9WTY7-mappedCitation-17372034 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17372034 |
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