| http://purl.uniprot.org/citations/17376403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17376403 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17376403 | http://www.w3.org/2000/01/rdf-schema#comment | "Low-density lipoprotein receptor-related protein 6 (LRP6) is a component of cell-surface receptors for Wnt proteins and Wnt is known to promote recruitment of Axin by LRP6 thereby inhibiting beta-catenin's degradation. We show here that growth factor receptor-bound protein10 (GRB10), a multi-modular adaptor protein that is known to associate with several transmembrane tyrosine kinase receptors, binds to the intracellular portion of LRP6 and negatively regulates Wnt signaling. GRB10 overexpression suppressed Wnt3a-, and LRP6-induced but not beta-catenin-induced TCF-dependent-reporter activities in HEK293T cells, suggesting that GRB10 functions upstream of beta-catenin. Actually, GRB10 overexpression attenuated the Wnt3a-induced accumulation of beta-catenin. In addition, RNAi-mediated down-regulation of endogenous GRB10 stimulated Wnt3a-induced reporter activities, indicating that GRB10 is indeed a novel negative regulator of the Wnt signaling pathway. The finding that GRB10 interferes with the binding of Axin to LRP6 indicated a possible molecular mechanism by which the overexpression of GRB10 suppresses Wnt signaling."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.03.019"xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2007.03.019"xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/author | "Brown A.M."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/author | "Brown A.M."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/author | "Yanagawa S."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/author | "Yanagawa S."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/author | "Tezuka N."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/author | "Tezuka N."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/name | "Biochem. Biophys. Res. Commun."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/pages | "648-654"xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/pages | "648-654"xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/title | "GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/title | "GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway."xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/volume | "356"xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://purl.uniprot.org/core/volume | "356"xsd:string |
| http://purl.uniprot.org/citations/17376403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17376403 |
| http://purl.uniprot.org/citations/17376403 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17376403 |
| http://purl.uniprot.org/citations/17376403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17376403 |
| http://purl.uniprot.org/citations/17376403 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17376403 |