| http://purl.uniprot.org/citations/1738193 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1738193 | http://www.w3.org/2000/01/rdf-schema#comment | "The BL/VL3 radiation leukemia virus is a nondefective retrovirus which induces clonal or oligoclonal T-cell leukemia in mice. To study the role of provirus insertional mutagenesis in the development of these neoplasias, we searched for common provirus integration sites in BL/VL3 radiation leukemia virus-induced tumors. Using cellular sequences flanking a provirus cloned from one of these thymomas, we found that the viral genome was integrated into a common region, designated Vin-1, in a low percentage (5%) of these tumors. The proviruses found in this locus were integrated in the same orientation, close to a CpG-rich island, at proximity of a transcriptional unit encoding a 6-kb RNA. Vin-1 RNA was detected in several organs of the adult mouse. Vin-1 RNA levels were high in tumors having a provirus inserted within the Vin-1 region but were also high in some other tumors whose Vin-1 region was not found to be rearranged. Vin-1 was found to be well conserved among mammalian species and was mapped to mouse chromosome 6, between raf and K-ras-2. Vin-1 appears to be a novel gene which may be involved in tumor development."xsd:string |
| http://purl.uniprot.org/citations/1738193 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.66.3.1344-1353.1992"xsd:string |
| http://purl.uniprot.org/citations/1738193 | http://purl.uniprot.org/core/author | "Kozak C.A."xsd:string |
| http://purl.uniprot.org/citations/1738193 | http://purl.uniprot.org/core/author | "Jolicoeur P."xsd:string |
| http://purl.uniprot.org/citations/1738193 | http://purl.uniprot.org/core/author | "Tremblay P.J."xsd:string |
| http://purl.uniprot.org/citations/1738193 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1738193 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/1738193 | http://purl.uniprot.org/core/pages | "1344-1353"xsd:string |
| http://purl.uniprot.org/citations/1738193 | http://purl.uniprot.org/core/title | "Identification of a novel gene, Vin-1, in murine leukemia virus-induced T-cell leukemias by provirus insertional mutagenesis."xsd:string |
| http://purl.uniprot.org/citations/1738193 | http://purl.uniprot.org/core/volume | "66"xsd:string |
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