| http://purl.uniprot.org/citations/17382984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17382984 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17382984 | http://www.w3.org/2000/01/rdf-schema#comment | "The alpha-conotoxin family is comprised of peptides that share the following arrangement of cysteine residues in the primary amino acid sequence: -CC-C-C-, where each dash represents a variable number of amino acids. The number of amino acids between cysteine residues has been used to group the alpha-conotoxins into distinct subfamilies. These subfamilies include the alpha 4/7-, alpha 4/3- and alpha 3/5-conotoxins, so named for the number of amino acids between 2nd/3rd and 3rd/4th cysteine residues, respectively. The alpha 3/5-conotoxins antagonize vertebrate-muscle nicotinic acetylcholine receptors (nAChRs), while the alpha 4/7- and alpha 4/3-conotoxins primarily inhibit vertebrate neuronal nAChRs. To date, these three subfamilies are the most extensively characterized of the alpha-conotoxin family. Here we report the purification and characterization of an unusual alpha 4/4-conotoxin, alpha-conotoxin PIB (alpha-PIB), from the venom of Conus purpurascens, with the following amino-acid sequence: ZSOGCCWNPACVKNRC (Z=pyroglutamate, O=hydroxyproline). This peptide demonstrates high affinity inhibition of vertebrate-muscle nAChRs, and paralytic effects when injected in vivo. Testing of alpha-PIB against other receptors indicated that the inhibitory effect is specific for skeletal muscle nAChRs. alpha-PIB shares the key biochemical and pharmacological characteristics of the alpha-conotoxin family."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2007.02.007"xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.toxicon.2007.02.007"xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Lopez-Vera E."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Lopez-Vera E."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Ellison M."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Ellison M."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Olivera B.M."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Jacobsen R.B."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Jacobsen R.B."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Teichert R.W."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/author | "Teichert R.W."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/name | "Toxicon"xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/pages | "1193-1199"xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/pages | "1193-1199"xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/title | "A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/title | "A novel alpha conotoxin (alpha-PIB) isolated from C. purpurascens is selective for skeletal muscle nicotinic acetylcholine receptors."xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/volume | "49"xsd:string |
| http://purl.uniprot.org/citations/17382984 | http://purl.uniprot.org/core/volume | "49"xsd:string |