| http://purl.uniprot.org/citations/17383861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17383861 | http://www.w3.org/2000/01/rdf-schema#comment | "Iron-mediated injury plays an important role in a number of heart disorders. Studies on heart iron are therefore crucial for understanding the causes of excessive heart iron. Heart cells have the ability to accumulate transferrin-bound-iron via the transferrin receptor and non-transferrin-bound-iron probably via the L-type Ca2+ channel and the divalent metal transporter1. However, little is known about the mechanisms of iron export in the heart cells. Here, we investigated expression of iron exporters including ferroportin 1 (Fpn1), ceruloplasmin (CP) and hephaestin (Heph) and provided evidence for their existence in the heart. We demonstrated that iron has a significant effect on expression of Fpn1 and CP, but not Heph. Treatment of a high-iron diet induced a significant increase in Fpn1, a decrease in CP but no change in Heph mRNA and protein. The control of Fpn1 and CP protein expression by iron was parallel to that of their mRNA expression, suggesting a transcriptional regulation of Fpn1 and CP by iron. The existence of these proteins in the heart implies that they might have a role in heart iron homeostasis."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbadis.2007.02.006"xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Niu L."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Wang Q."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Zhu L."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Yang L."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Leung G."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Xu Y.J."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Ke Y."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Ho K.P."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Chang Y.Z."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Qian Z.M."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/author | "Du J.R."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/pages | "527-532"xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/title | "Expression of ferroportin1, hephaestin and ceruloplasmin in rat heart."xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://purl.uniprot.org/core/volume | "1772"xsd:string |
| http://purl.uniprot.org/citations/17383861 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17383861 |
| http://purl.uniprot.org/citations/17383861 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17383861 |
| http://purl.uniprot.org/uniprot/#_A6IHC3-mappedCitation-17383861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17383861 |
| http://purl.uniprot.org/uniprot/#_A6IHC4-mappedCitation-17383861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17383861 |
| http://purl.uniprot.org/uniprot/#_A6IHC5-mappedCitation-17383861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17383861 |
| http://purl.uniprot.org/uniprot/#_A0A8I6A708-mappedCitation-17383861 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17383861 |