| http://purl.uniprot.org/citations/17384673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17384673 | http://www.w3.org/2000/01/rdf-schema#comment | "Nonhomologous end joining (NHEJ) is a critical DNA repair pathway, with proposed tumor suppression functions in many tissues. Mutations in the NHEJ factor ARTEMIS cause radiation-sensitive severe combined immunodeficiency in humans and may increase susceptibility to lymphoma in some settings. We now report that deficiency for Artemis (encoded by Dclre1c/Art in mouse) accelerates tumorigenesis in several tissues in a Trp53 heterozygous setting, revealing tumor suppression roles for NHEJ in lymphoid and non-lymphoid cells. We also show that B-lineage lymphomas in these mice undergo loss of Trp53 heterozygosity by allele replacement, but arise by mechanisms distinct from those in Art Trp53 double null mice. These findings demonstrate a general tumor suppression function for NHEJ, and reveal that interplay between NHEJ and Trp53 loss of heterozygosity influences the sequence of multi-hit oncogenesis. We present a model where p53 status at the time of tumor initiation is a key determinant of subsequent oncogenic mechanisms. Because Art deficient mice represent a model for radiation-sensitive severe combined immunodeficiency, our findings suggest that these patients may be at risk for both lymphoid and non-lymphoid cancers."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1210430"xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Bronson R.T."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Foreman O."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Shaffer D."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Maas S.A."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Woo Y."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Affourtit J."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Kamdar S."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Roopenian D."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Morse H.C."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Akeson E.C."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Mills K.D."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Caddle L.B."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Wright S.M."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/author | "Alley T.L."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/pages | "6010-6020"xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/title | "The nonhomologous end joining factor Artemis suppresses multi-tissue tumor formation and prevents loss of heterozygosity."xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://purl.uniprot.org/core/volume | "26"xsd:string |
| http://purl.uniprot.org/citations/17384673 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17384673 |
| http://purl.uniprot.org/citations/17384673 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17384673 |
| http://purl.uniprot.org/uniprot/#_A0A158SIS7-mappedCitation-17384673 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17384673 |