| http://purl.uniprot.org/citations/17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17385724 | http://www.w3.org/2000/01/rdf-schema#comment | "The capsaicin receptor, transient receptor potential, vanilloid type 1 (TRPV1), is a Ca(2+)-permeable ion channel activated by noxious stimuli eliciting pain. Several reports have shown modulation of TRPV1 activity and expression by neuronal growth factors. Here, we study the long-term effects on TRPV1 expression mediated by insulin-like growth factor type-I (IGF-I) and insulin in a stably TRPV1-expressing SH-SY5Y neuroblastoma cell line. We show that, after 72 hr of 10 nM IGF-I or insulin exposure, the TRPV1 protein level was up-regulated 2.5- and 2-fold, respectively. By blocking phosphatidylinositol-3-kinase [PI(3)K] or mitogen-activated protein kinase (MAPK) signaling, we concluded that the increase in total TRPV1 protein content induced by IGF-I was controlled by PI(3)K signaling, whereas insulin seemed to regulate TRPV1 protein expression via both PI(3)K and MAPK pathways. Inhibiting protein kinase C (PKC) blocked the effects of both IGF-I and insulin. Furthermore, the concentrations causing a 50% Ca(2+) increase (EC(50)) after insulin and IGF-I treatments were significantly lowered compared with untreated cells. We conclude that IGF-I and insulin enhance TRPV1 protein expression and activity, and impaired pain sensation might result from distorted TRPV1 regulation in the peripheral nervous system."xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://purl.org/dc/terms/identifier | "doi:10.1002/jnr.21255"xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://purl.uniprot.org/core/author | "Lilja J."xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://purl.uniprot.org/core/author | "Forsby A."xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://purl.uniprot.org/core/author | "Laulund F."xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17385724 | http://purl.uniprot.org/core/name | "J Neurosci Res"xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://purl.uniprot.org/core/pages | "1413-1419"xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://purl.uniprot.org/core/title | "Insulin and insulin-like growth factor type-I up-regulate the vanilloid receptor-1 (TRPV1) in stably TRPV1-expressing SH-SY5Y neuroblastoma cells."xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://purl.uniprot.org/core/volume | "85"xsd:string |
| http://purl.uniprot.org/citations/17385724 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17385724 |
| http://purl.uniprot.org/citations/17385724 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17385724 |
| http://purl.uniprot.org/uniprot/#_A0A1U9WZ84-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q13429-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q09HS5-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q52PU4-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_P05019-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q5U743-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q3LU46-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q6LD41-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q8IZY9-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q59GC5-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q8NER1-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |
| http://purl.uniprot.org/uniprot/#_Q9NP10-mappedCitation-17385724 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17385724 |