| http://purl.uniprot.org/citations/17387146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17387146 | http://www.w3.org/2000/01/rdf-schema#comment | "Apoptosis is critical for embryonic development, tissue homeostasis, and tumorigenesis and is determined largely by the Bcl-2 family of antiapoptotic and prosurvival regulators. Here, we report that glycogen synthase kinase 3 (GSK-3) was required for Mcl-1 degradation, and we identified a novel mechanism for proteasome-mediated Mcl-1 turnover in which GSK-3beta associates with and phosphorylates Mcl-1 at one consensus motif ((155)STDG(159)SLPS(163)T; phosphorylation sites are in italics), which will lead to the association of Mcl-1 with the E3 ligase beta-TrCP, and beta-TrCP then facilitates the ubiquitination and degradation of phosphorylated Mcl-1. A variant of Mcl-1 (Mcl-1-3A), which abolishes the phosphorylations by GSK-3beta and then cannot be ubiquitinated by beta-TrCP, is much more stable than wild-type Mcl-1 and able to block the proapoptotic function of GSK-3beta and enhance chemoresistance. Our results indicate that the turnover of Mcl-1 by beta-TrCP is an essential mechanism for GSK-3beta-induced apoptosis and contributes to GSK-3beta-mediated tumor suppression and chemosensitization."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00620-06"xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Xia W."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Zhong Q."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Li L.Y."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Ding Q."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Hung M.C."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Liu J.C."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Chen C.T."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Hsu J.M."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/author | "Lee D.F."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/pages | "4006-4017"xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/title | "Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization."xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/17387146 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17387146 |
| http://purl.uniprot.org/citations/17387146 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17387146 |
| http://purl.uniprot.org/uniprot/#_A0A087WT64-mappedCitation-17387146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387146 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z4Q5-mappedCitation-17387146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387146 |
| http://purl.uniprot.org/uniprot/#_A0A0S2Z507-mappedCitation-17387146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387146 |
| http://purl.uniprot.org/uniprot/#_A0A286YDI3-mappedCitation-17387146 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387146 |