| http://purl.uniprot.org/citations/17387333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17387333 | http://www.w3.org/2000/01/rdf-schema#comment | "Temporal lobe epilepsy patients remain refractory to available anti-epileptic drugs in 30% of cases, indicating a need for novel therapeutic strategies. In this context, glial cell line-derived neurotrophic factor (GDNF) emerges as a possible new agent for epilepsy treatment. However, a limited number of studies, use of different epilepsy models, and different methods of GDNF delivery preclude understanding of the mechanisms for the seizure-suppressant action of GDNF. Here we show that recombinant adeno-associated viral (rAAV) vector-based GDNF overexpression in the rat hippocampus suppresses seizures in two models of temporal lobe epilepsy. First, when rAAV-GDNF was injected before hippocampal kindling, the number of generalized seizures decreased, and the prolongation of behavioral convulsions in fully kindled animals was prevented. Second, injection of rAAV-GDNF after kindling increased the seizure induction threshold. Third, rAAV-GDNF decreased the frequency of generalized seizures during the self-sustained phase of status epilepticus. Our data demonstrate the complexity of mechanisms and the beneficial action of GDNF in epilepsy. Furthermore, we show that ectopic rAAV-mediated GDNF gene expression in the seizure focus is a feasible way to mitigate seizures and provides proof of principle that the neurotrophic factor-based gene therapy approach has the potential to be developed as alternative strategy for epilepsy treatment."xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.mt.6300148"xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/author | "Kirik D."xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/author | "Kokaia M."xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/author | "Georgievska B."xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/author | "Kanter-Schlifke I."xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/name | "Mol Ther"xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/pages | "1106-1113"xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/title | "Seizure suppression by GDNF gene therapy in animal models of epilepsy."xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/17387333 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17387333 |
| http://purl.uniprot.org/citations/17387333 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17387333 |
| http://purl.uniprot.org/uniprot/#_A7UGI9-mappedCitation-17387333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/#_A7UGJ0-mappedCitation-17387333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/#_A7UGJ1-mappedCitation-17387333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/#_A7UGJ2-mappedCitation-17387333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/#_A6KGH0-mappedCitation-17387333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/#_A6KGH1-mappedCitation-17387333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/#_Q07731-mappedCitation-17387333 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/A7UGI9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/A7UGJ0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/A6KGH1 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17387333 |
| http://purl.uniprot.org/uniprot/A6KGH0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17387333 |