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http://purl.uniprot.org/citations/17389404http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17389404http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17389404http://www.w3.org/2000/01/rdf-schema#comment"Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.org/dc/terms/identifier"doi:10.1073/pnas.0701297104"xsd:string
http://purl.uniprot.org/citations/17389404http://purl.org/dc/terms/identifier"doi:10.1073/pnas.0701297104"xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Hinds M.G."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Hinds M.G."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Czabotar P.E."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Czabotar P.E."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Smith B.J."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Smith B.J."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Colman P.M."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Colman P.M."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Fairlie W.D."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Fairlie W.D."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Day C.L."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Day C.L."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Huang D.C.S."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Huang D.C.S."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Lee E.F."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"Lee E.F."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"van Delft M.F."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/author"van Delft M.F."xsd:string
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17389404http://purl.uniprot.org/core/date"2007"xsd:gYear