| http://purl.uniprot.org/citations/17389684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17389684 | http://www.w3.org/2000/01/rdf-schema#comment | "The two principal functions of ovarian follicles are developmental and endocrine. The cumulus cells surrounding the oocyte are specialized to serve the development of the oocyte and steroidogenesis is a principal role of mural granulosa cells that line the follicle wall. The findings in this report demonstrate that oocytectomy or treatment with an inhibitor of SMAD2/3 activation results in decreased cumulus marker mRNA transcript levels and allows FSH to induce mural marker transcripts in cumulus cells. In addition, SMAD2/3 signaling is involved in enabling cumulus expansion and EGF-induced increases in Ptx3, Ptgs2 and Has2 mRNA levels. By contrast, follicle-stimulating hormone (FSH) stimulated expression of mural transcripts, but suppressed levels of cumulus transcripts. Thus, FSH and oocyte-stimulated SMAD2/3 signaling establish opposing gradients of influence in the follicle. These specify the mural and cumulus granulosa cell phenotypes that are pivotal for appropriate endocrine function and oocyte development."xsd:string |
| http://purl.uniprot.org/citations/17389684 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.000968"xsd:string |
| http://purl.uniprot.org/citations/17389684 | http://purl.uniprot.org/core/author | "Eppig J.J."xsd:string |
| http://purl.uniprot.org/citations/17389684 | http://purl.uniprot.org/core/author | "Wigglesworth K."xsd:string |
| http://purl.uniprot.org/citations/17389684 | http://purl.uniprot.org/core/author | "Diaz F.J."xsd:string |
| http://purl.uniprot.org/citations/17389684 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17389684 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/17389684 | http://purl.uniprot.org/core/pages | "1330-1340"xsd:string |
| http://purl.uniprot.org/citations/17389684 | http://purl.uniprot.org/core/title | "Oocytes determine cumulus cell lineage in mouse ovarian follicles."xsd:string |
| http://purl.uniprot.org/citations/17389684 | http://purl.uniprot.org/core/volume | "120"xsd:string |
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