| http://purl.uniprot.org/citations/17390040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17390040 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, gene fusions between the androgen responsive gene TMPRSS2 and members of the ETS-family of DNA-binding transcription factor genes were found in prostate cancer. Recurrent fusions were identified between the 5'-noncoding region of TMPRSS2 and ERG, or less frequently ETV1 or ETV4, resulting in overexpression of normal or truncated ETS-proteins. Herein, we have analyzed a series of 50 prostate cancer samples for expression of TPRSS2-ERG and TMPRSS2-ETV1 fusion transcripts. RT-PCR analysis revealed TMPRSS2-ERG fusion transcripts in 18 of the 50 tumors (36%). None of the tumors expressed a TMPRSS2-ETV1 fusion. Our findings show that the TMPRSS2-ERG fusion is common in prostate cancer and that the related TMPRSS2-ETV1 fusion is very rare. However, the frequency of ERG-fusions in the present study is somewhat lower than previously observed, indicating heterogeneity with regard to expression of ETS-gene fusions in subsets of prostate cancers. Moreover, clinical follow-up studies showed a clear tendency that fusion-positive tumors were associated with lower Gleason grade and better survival than fusion-negative tumors. Our findings suggest that ERG gene fusions might be of prognostic significance in prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/author | "Stenman G."xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/author | "Winnes M."xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/author | "Damber J.E."xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/author | "Lissbrant E."xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/name | "Oncol Rep"xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/pages | "1033-1036"xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/title | "Molecular genetic analyses of the TMPRSS2-ERG and TMPRSS2-ETV1 gene fusions in 50 cases of prostate cancer."xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/17390040 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17390040 |
| http://purl.uniprot.org/citations/17390040 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17390040 |
| http://purl.uniprot.org/uniprot/#_B7Z1R4-mappedCitation-17390040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/#_B7Z2C9-mappedCitation-17390040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/#_B5MCT2-mappedCitation-17390040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/#_P50549-mappedCitation-17390040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/#_O15393-mappedCitation-17390040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/#_Q8WYS7-mappedCitation-17390040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/#_Q96T73-mappedCitation-17390040 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/Q96T73 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/Q8WYS7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/O15393 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/B7Z2C9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17390040 |
| http://purl.uniprot.org/uniprot/P50549 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17390040 |