| http://purl.uniprot.org/citations/17392269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17392269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17392269 | http://www.w3.org/2000/01/rdf-schema#comment | "The Drosophila gene, pixie, is an essential gene required for normal growth and translation. Pixie is the fly ortholog of human RLI, which was first identified as an RNase L inhibitor, and yeast Rli1p, which has recently been shown to play a role in translation initiation and ribosome biogenesis. These proteins are all soluble ATP-binding cassette proteins with two N-terminal iron-sulfur clusters. Here we demonstrate that Pixie can be isolated from cells in complex with eukaryotic translation initiation factor 3 and ribosomal proteins of the small subunit. In addition, our analysis of polysome profiles reveals that double-stranded RNA interference-mediated depletion of Pixie results in an increase in empty 80 S ribosomes and a corresponding decrease in polysomes. Thus Pixie is required for normal levels of translation initiation. We also find that Pixie associates with the 40 S subunit on sucrose density gradients in an ATP-dependent manner. Our observations are consistent with Pixie playing a catalytic role in the assembly of complexes required for translation initiation. Thus, the function of this soluble ATP-binding cassette domain protein family in translation initiation has been conserved from yeast through to higher eukaryotes."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701361200"xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701361200"xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/author | "Andersen D.S."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/author | "Andersen D.S."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/author | "Leevers S.J."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/author | "Leevers S.J."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/pages | "14752-14760"xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/pages | "14752-14760"xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/title | "The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/title | "The essential Drosophila ATP-binding cassette domain protein, pixie, binds the 40 S ribosome in an ATP-dependent manner and is required for translation initiation."xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://purl.uniprot.org/core/volume | "282"xsd:string |
| http://purl.uniprot.org/citations/17392269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17392269 |
| http://purl.uniprot.org/citations/17392269 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17392269 |
| http://purl.uniprot.org/citations/17392269 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17392269 |
| http://purl.uniprot.org/citations/17392269 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17392269 |
| http://purl.uniprot.org/uniprot/Q9VSS1 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17392269 |
| http://purl.uniprot.org/uniprot/Q0E940 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/17392269 |