| http://purl.uniprot.org/citations/17392428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17392428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17392428 | http://www.w3.org/2000/01/rdf-schema#comment | "The proteasome maintains cellular homeostasis by degrading oxidized and damaged proteins, a function known to be impaired during aging. The proteasome also acts in a regulatory capacity through E3 ligases to mediate the spatially and temporally controlled breakdown of specific proteins that impact biological processes. We have identified components of a Skp1-Cul1-F-Box E3 ligase complex that are required for the extended lifespan of Caenorhabditis elegans insulin/insulin-like growth factor-1-signaling (IIS) mutants. The CUL-1 complex functions in postmitotic, adult somatic tissues of IIS mutants to enhance longevity. Reducing IIS function leads to the nuclear accumulation of the DAF-16/FOXO transcription factor, which extends lifespan by regulating downstream longevity genes. These CUL-1 complex genes act, at least in part, by promoting the transcriptional activity of DAF-16/FOXO. Together, our findings describe a role for an important cellular pathway, the proteasomal pathway, in the genetic determination of lifespan."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0700638104"xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0700638104"xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/author | "Kenyon C."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/author | "Kenyon C."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/author | "Ghazi A."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/author | "Ghazi A."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/author | "Henis-Korenblit S."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/author | "Henis-Korenblit S."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/pages | "5947-5952"xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/pages | "5947-5952"xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/title | "Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/title | "Regulation of Caenorhabditis elegans lifespan by a proteasomal E3 ligase complex."xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17392428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17392428 |
| http://purl.uniprot.org/citations/17392428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17392428 |
| http://purl.uniprot.org/citations/17392428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17392428 |
| http://purl.uniprot.org/citations/17392428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17392428 |