| http://purl.uniprot.org/citations/17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17392823 | http://www.w3.org/2000/01/rdf-schema#comment | "Selectins are carbohydrate-binding molecules involved in constitutive lymphocyte homing and chronic and acute inflammation processes. Th1 lymphocytes participate in cell-mediated inflammatory reactions, where the selectins play a role and predominate in delayed-type hypersensitivity (DTH) reactions of the skin. Of the many candidate ligands for selectins, only P-selectin glycoprotein ligand 1 (PSGL-1), which also acts as an E-selectin ligand, has been characterized extensively at molecular, cellular, and functional levels on T cells. Here, we report that the glycosylated form of CD43 expressed in Th1 cells is a functional E-selectin-specific ligand in vitro. Furthermore, we have generated PSGL-1(-/-)/CD43(-/-) double-deficient mice (double knockout (DKO)) to demonstrate the relevance of CD43 as an E-selectin ligand in vitro and in vivo. Under flow conditions, DKO Th1 cells exhibited impaired E-selectin binding as compared with wild-type, PSGL-1(-/-), or CD43(-/-) Th1 cells. DKO mice also showed diminished ear inflammation in response to dinitrofluorobenzene-induced DTH that correlated with a reduced number of T cells in infiltrates in the challenged ear. These results demonstrate that both PSGL-1 and CD43 are major E-selectin ligands and are likely to be important during leukocyte recruitment in the development of inflammatory reactions."xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.jid.5700805"xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/author | "Alcaide P."xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/author | "Luscinskas F.W."xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/author | "King S.L."xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/author | "Lim Y.C."xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/author | "Fuhlbrigge R.C."xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/author | "Dimitroff C.J."xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/pages | "1964-1972"xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/title | "The 130-kDa glycoform of CD43 functions as an E-selectin ligand for activated Th1 cells in vitro and in delayed-type hypersensitivity reactions in vivo."xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://purl.uniprot.org/core/volume | "127"xsd:string |
| http://purl.uniprot.org/citations/17392823 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17392823 |
| http://purl.uniprot.org/citations/17392823 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17392823 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YTY7-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YUH7-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |
| http://purl.uniprot.org/uniprot/#_A0A0J9YV23-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNN5-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JF74-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |
| http://purl.uniprot.org/uniprot/#_Q62170-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |
| http://purl.uniprot.org/uniprot/#_P15702-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |
| http://purl.uniprot.org/uniprot/#_Q99L34-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |
| http://purl.uniprot.org/uniprot/#_Q3TA56-mappedCitation-17392823 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392823 |