| http://purl.uniprot.org/citations/17392825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17392825 | http://www.w3.org/2000/01/rdf-schema#comment | "Extracellular superoxide dismutase (EC-SOD) is primarily a tissue enzyme and has been implicated in the modulation of inflammatory response. The biological role of EC-SOD in skin, however, has rarely been investigated. In this study, we aim to explore the effects of EC-SOD on the inflammatory response in skin by evaluating the contact hypersensitivity response (CHS) in EC-SOD transgenic mice. Transgenic mice with skin-specific expression of EC-SOD were sensitized and challenged with 2,4,6-trinitro-1-chlorobenzene (TNCB), followed by measurement of ear swelling. EC-SOD transgenic mice showed significantly reduced CHS responses compared with wild-type mice. Histological evaluation of the challenged ears of EC-SOD transgenic mice revealed diminished infiltration of inflammatory cells with a failure to induce expression of inflammatory cytokines, such as tumor necrosis factor-alpha and IFN-gamma, on sensitization and challenge with TNCB. Furthermore, Langerhans cell migration to lymph nodes was impaired in EC-SOD transgenic mice. These results indicate that EC-SOD downregulates CHS through inhibition of the inflammatory response, suggesting a possible therapeutic regimen in inflammatory skin diseases."xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.jid.5700802"xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/author | "Kim T.Y."xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/author | "Park S.T."xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/author | "Kim K.E."xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/author | "Na K."xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/name | "J Invest Dermatol"xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/pages | "1930-1937"xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/title | "EC-SOD suppresses contact hypersensitivity in mouse skin by impairing Langerhans cell migration."xsd:string |
| http://purl.uniprot.org/citations/17392825 | http://purl.uniprot.org/core/volume | "127"xsd:string |
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| http://purl.uniprot.org/uniprot/#_O09164-mappedCitation-17392825 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17392825 |
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