| http://purl.uniprot.org/citations/17395341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17395341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17395341 | http://www.w3.org/2000/01/rdf-schema#comment | "Recombinant botulinum Hc (rBoNT Hc) vaccines for serotypes C1 and D were produced in the yeast Pichia pastoris and used to determine protection against four distinct BoNT C and D toxin subtypes. Mice were vaccinated with rBoNT/C1 Hc, rBoNT/D Hc, or with a combination of both vaccines and challenged with BoNT C1, D, C/D, or D/C toxin. Mice receiving monovalent vaccinations were partially or completely protected against homologous toxin and not protected against heterologous toxin. Bivalent vaccine candidates completely survived challenges from all toxins except D/C toxin. These results indicate the recombinant C1 and D Hc vaccines are not only effective in a monovalent formula but offer complete protection against both parental and C/D mosaic toxin and partial protection against D/C mosaic toxin when delivered as a bivalent vaccine."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.vaccine.2007.02.081"xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.vaccine.2007.02.081"xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Smith T.J."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Smith T.J."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Smith L.A."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Smith L.A."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Meagher M.M."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Meagher M.M."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Montgomery V.A."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Montgomery V.A."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Webb R.P."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Webb R.P."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Wright P.M."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/author | "Wright P.M."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/name | "Vaccine"xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/name | "Vaccine"xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/pages | "4273-4282"xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/pages | "4273-4282"xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/title | "Protection with recombinant Clostridium botulinum C1 and D binding domain subunit (Hc) vaccines against C and D neurotoxins."xsd:string |
| http://purl.uniprot.org/citations/17395341 | http://purl.uniprot.org/core/title | "Protection with recombinant Clostridium botulinum C1 and D binding domain subunit (Hc) vaccines against C and D neurotoxins."xsd:string |