Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/17398123http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17398123http://www.w3.org/2000/01/rdf-schema#comment"Despite constant contact with the large population of commensal bacteria, the colonic mucosa is normally hyporesponsive to these potentially proinflammatory signals. Here we report that the single immunoglobulin IL-1 receptor-related molecule (SIGIRR), a negative regulator for Toll-IL-1R signaling, plays a critical role in gut homeostasis, intestinal inflammation, and colitis-associated tumorigenesis by maintaining the microbial tolerance of the colonic epithelium. SIGIRR-deficient (Sigirr(-/-)) colonic epithelial cells displayed commensal bacteria-dependent homeostatic defects, as shown by constitutive upregulation of inflammatory genes, increased inflammatory responses to dextran sulfate sodium (DSS) challenge, and increased Azoxymethane (AOM)+DSS-induced colitis-associated tumorigenesis. Gut epithelium-specific expression of the SIGIRR transgene in the SIGIRR-deficient background reduced the cell survival of the SIGIRR-deficient colon epithelium, abrogated the hypersensitivity of the Sigirr(-/-) mice to DSS-induced colitis, and reduced AOM+DSS-induced tumorigenesis. Taken together, our results indicate that epithelium-derived SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.org/dc/terms/identifier"doi:10.1016/j.immuni.2007.02.012"xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Li X."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Ma C."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Zhou H."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Qin J."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Yao J."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Xiao H."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Gulen M.F."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Vallance B.A."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Wald D."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Bulek K."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Altuntas C.Z."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Tuohy V.K."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Kish D."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Fairchild R.L."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"de la Motte C."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/author"Cua D."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/name"Immunity"xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/pages"461-475"xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/title"The Toll-interleukin-1 receptor member SIGIRR regulates colonic epithelial homeostasis, inflammation, and tumorigenesis."xsd:string
http://purl.uniprot.org/citations/17398123http://purl.uniprot.org/core/volume"26"xsd:string
http://purl.uniprot.org/citations/17398123http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17398123
▶