| http://purl.uniprot.org/citations/1739968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1739968 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1739968 | http://www.w3.org/2000/01/rdf-schema#comment | "We show that phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2) by the protein kinase GCN2 mediates translational control of the yeast transcriptional activator GCN4. In vitro, GCN2 specifically phosphorylates the alpha subunit of rabbit or yeast eIF-2. In vivo, phosphorylation of eIF-2 alpha increases in response to amino acid starvation, which is dependent on GCN2. Substitution of Ser-51 with alanine eliminates phosphorylation of eIF-2 alpha by GCN2 in vivo and in vitro and abolishes increased expression of GCN4 and amino acid biosynthetic genes under its control in amino acid-starved cells. The Asp-51 substitution mimics the phosphorylated state and derepresses GCN4 in the absence of GCN2. Thus, an established mechanism for regulating total protein synthesis in mammalian cells mediates gene-specific translational control in yeast."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90193-g"xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.org/dc/terms/identifier | "doi:10.1016/0092-8674(92)90193-g"xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Feng L."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Wek R.C."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Wek R.C."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Hinnebusch A.G."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Hinnebusch A.G."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Dever T.E."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Dever T.E."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Cigan A.M."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Cigan A.M."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Donahue T.F."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/author | "Donahue T.F."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/pages | "585-596"xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/pages | "585-596"xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/title | "Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast."xsd:string |
| http://purl.uniprot.org/citations/1739968 | http://purl.uniprot.org/core/title | "Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast."xsd:string |