| http://purl.uniprot.org/citations/17400545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17400545 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17400545 | http://www.w3.org/2000/01/rdf-schema#comment | "R-spondin proteins are newly identified secreted molecules that activate beta-catenin signaling. However, the mechanism of R-spondin action and its relationship with Wnt signaling remain unclear. Here we show that human R-spondin1 (hRspo1) is a high affinity ligand for the Wnt co-receptor LRP6 (K(d) = 1.2 nm). hRspo1 induces glycogen synthase kinase 3-dependent phosphorylation and activation of LRP6. DKK1, an LRP6 antagonist, inhibits hRspo1-induced LRP6 phosphorylation. We further demonstrate that hRspo1 synergizes with Frizzled5 in Xenopus axis induction assays and induces the phosphorylation of Dishevelled, a cytoplasmic component downstream of Frizzled function. Our study reveals interesting similarity and distinction between Wnt and R-spondin signaling."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701927200"xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m701927200"xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Wei Q."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Woodgett J."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Woodgett J."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Semenov M.V."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Semenov M.V."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Doble B."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Doble B."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Yokota C."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/author | "Yokota C."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/pages | "15903-15911"xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/pages | "15903-15911"xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/title | "R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling."xsd:string |
| http://purl.uniprot.org/citations/17400545 | http://purl.uniprot.org/core/title | "R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signaling."xsd:string |