| http://purl.uniprot.org/citations/17400713 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17400713 | http://www.w3.org/2000/01/rdf-schema#comment | "Vascular endothelial growth factor (VEGF)-C plays an important role in lymphangiogenesis; however, functional responses of lymphatic vessels to VEGF-C have not been characterized. We tested the hypothesis that VEGF-C-induced activation of VEGF receptor (VEGFR)-3 increases lymphatic pump output. We examined the in vivo pump activity of rat mesenteric collecting lymphatics using intravital microscopy during basal conditions and during treatment with 1 nM recombinant VEGF-C, the selective VEGFR-3 agonist VEGF-Cys(156)Ser mutation (C156S; 1 nM), or 0.1 nM VEGF-A. Their specific responses were also analyzed during selective inhibition of VEGFR-3 with MAZ-51. Contraction frequency, end-diastolic diameter, end-systolic diameter, stroke volume index, pump flow index, and ejection fraction were evaluated. We also assessed arteriolar diameter and microvascular extravasation of FITC-albumin. The results show that both VEGF-C and VEGF-C156S significantly increased contraction frequency, end-diastolic diameter, stroke volume index, and pump flow index in a time-dependent manner. VEGF-A caused a different response characterized by a significantly increased stroke volume after 30 min of treatment. MAZ-51 (5 muM) caused tonic constriction and decreased contraction frequency. In addition, 0.5 and 5 muM MAZ-51 attenuated VEGF-C- and VEGF-C156S-induced lymphatic pump activation. VEGF-A caused vasodilation of arterioles, whereas VEGF-C and VEGF-C156S did not significantly alter arteriolar diameter. Also, VEGF-A and VEGF-C caused increased microvascular permeability, whereas VEGF-C156S did not. Our results demonstrate that VEGF-C increases lymphatic pumping through VEGFR-3. Furthermore, changes in microvascular hemodynamics are not required for VEGFR-3-mediated changes in lymphatic pump activity."xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpheart.00102.2007"xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/author | "Wu M.H."xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/author | "Yuan S.Y."xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/author | "Breslin J.W."xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/author | "Reynoso R."xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/author | "Watson K.D."xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/author | "Gaudreault N."xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/name | "Am J Physiol Heart Circ Physiol"xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/pages | "H709-18"xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/title | "Vascular endothelial growth factor-C stimulates the lymphatic pump by a VEGF receptor-3-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/17400713 | http://purl.uniprot.org/core/volume | "293"xsd:string |
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