| http://purl.uniprot.org/citations/17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17403042 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite a dogma that apoptosis does not induce inflammation, Fas ligand (FasL), a well-known death factor, possesses pro-inflammatory activity. For example, FasL induces nuclear factor kappaB (NF-kappaB) activity and interleukin 8 (IL-8) production by engagement of Fas in human cells. Here, we found that a dominant negative mutant of c-Jun, a component of the activator protein-1 (AP-1) transcription factor, inhibits FasL-induced AP-1 activity and IL-8 production in HEK293 cells. Selective inhibition of AP-1 did not affect NF-kappaB activation and vice versa, indicating that their activations were not sequential events. The FasL-induced AP-1 activation could be inhibited by deleting or introducing the lymphoproliferation (lpr)-type point mutation into the Fas death domain (DD), knocking down the Fas-associated DD protein (FADD), abrogating caspase-8 expression with small interfering RNAs, or using inhibitors for pan-caspase and caspase-8 but not caspase-1 or caspase-3. Furthermore, wildtype, but not a catalytically inactive mutant, of caspase-8 reconstituted the FasL-induced AP-1 activation in caspase-8-deficient cells. Fas ligand induced the phosphorylation of two of the three major mitogen-activated protein kinases (MAPKs): extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) but not p38 MAPK. Unexpectedly, an inhibitor for JNK but not for MAPK/ERK kinase inhibited the FasL-induced AP-1 activation and IL-8 production. These results demonstrate that FasL-induced AP-1 activation is required for optimal IL-8 production, and this process is mediated by FADD, caspase-8, and JNK."xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1742-4658.2007.05772.x"xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://purl.uniprot.org/core/author | "Matsumoto N."xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://purl.uniprot.org/core/author | "Suda T."xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://purl.uniprot.org/core/author | "Imamura R."xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17403042 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://purl.uniprot.org/core/pages | "2376-2384"xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://purl.uniprot.org/core/title | "Caspase-8- and JNK-dependent AP-1 activation is required for Fas ligand-induced IL-8 production."xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://purl.uniprot.org/core/volume | "274"xsd:string |
| http://purl.uniprot.org/citations/17403042 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17403042 |
| http://purl.uniprot.org/citations/17403042 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17403042 |
| http://purl.uniprot.org/uniprot/#_A0A510GAI3-mappedCitation-17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/#_A1Y9B0-mappedCitation-17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/#_Q7TMV9-mappedCitation-17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/#_P41047-mappedCitation-17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/#_P05412-mappedCitation-17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/#_Q544E9-mappedCitation-17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/#_Q6FHK0-mappedCitation-17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/#_Q99PH8-mappedCitation-17403042 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/Q6FHK0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/A0A510GAI3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/P05412 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17403042 |
| http://purl.uniprot.org/uniprot/A1Y9B0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17403042 |