| http://purl.uniprot.org/citations/17403373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17403373 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17403373 | http://www.w3.org/2000/01/rdf-schema#comment | "GLUT4 trafficking to the plasma membrane of muscle and fat cells is regulated by insulin. An important component of insulin-regulated GLUT4 distribution is the Akt substrate AS160 rab GTPase-activating protein. Here we show that Rab10 functions as a downstream target of AS160 in the insulin-signaling pathway that regulates GLUT4 translocation in adipocytes. Overexpression of a mutant of Rab10 defective for GTP hydrolysis increased GLUT4 on the surface of basal adipocytes. Rab10 knockdown resulted in an attenuation of insulin-induced GLUT4 redistribution to the plasma membrane and a concomitant 2-fold decrease in GLUT4 exocytosis rate. Re-expression of a wild-type Rab10 restored normal GLUT4 translocation. The basal increase in plasma-membrane GLUT4 due to AS160 knockdown was partially blocked by knocking down Rab10 in the same cells, further indicating that Rab10 is a target of AS160 and a positive regulator of GLUT4 trafficking to the cell surface upon insulin stimulation."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2007.03.001"xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2007.03.001"xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Fukuda M."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Fukuda M."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Sano H."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Sano H."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Lienhard G.E."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Lienhard G.E."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Eguez L."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Eguez L."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Chavez J.A."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Chavez J.A."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "McGraw T.E."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "McGraw T.E."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Teruel M.N."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Teruel M.N."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Chuang T.D."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/author | "Chuang T.D."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/name | "Cell Metab."xsd:string |
| http://purl.uniprot.org/citations/17403373 | http://purl.uniprot.org/core/name | "Cell Metab."xsd:string |