| http://purl.uniprot.org/citations/17403780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17403780 | http://www.w3.org/2000/01/rdf-schema#comment | "The circadian rhythm of pineal melatonin requires the nocturnal increment of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) protein. To date, only limited information is available in the critical issue of how AANAT protein expression is up-regulated exclusively at night regardless of its species-specific mRNA profiles. Here we show that the circadian timing of AANAT protein expression is regulated by rhythmic translation of AANAT mRNA. This rhythmic control is mediated by both a highly conserved IRES (internal ribosome entry site) element within the AANAT 5' untranslated region and its partner hnRNP Q (heterogeneous nuclear ribonucleoprotein Q) with a peak in the middle of the night. Consistent with the enhancing role of hnRNP Q in AANAT IRES activities, knockdown of the hnRNP Q level elicited a dramatic decrease of peak amplitude in the AANAT protein profile parallel to reduced melatonin production in pinealocytes. This translational regulation of AANAT mRNA provides a novel aspect for achieving the circadian rhythmicity of vertebrate melatonin."xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.1519507"xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/author | "Cho S."xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/author | "Kim K.T."xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/author | "Woo K.C."xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/author | "Jang S.K."xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/author | "Kim T.D."xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/author | "Ha D.C."xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/pages | "797-810"xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/title | "Rhythmic control of AANAT translation by hnRNP Q in circadian melatonin production."xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://purl.uniprot.org/core/volume | "21"xsd:string |
| http://purl.uniprot.org/citations/17403780 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17403780 |
| http://purl.uniprot.org/citations/17403780 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17403780 |
| http://purl.uniprot.org/uniprot/Q7TP47#attribution-A3418AF2464D187F15F5AE3C99FF0C1A | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17403780 |
| http://purl.uniprot.org/uniprot/Q7TP47#attribution-FB83EF1BA0647298021DA2991D2F4210 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17403780 |
| http://purl.uniprot.org/uniprot/#_A0A0G2K9J1-mappedCitation-17403780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403780 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZXH7-mappedCitation-17403780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403780 |
| http://purl.uniprot.org/uniprot/#_A0A8I5ZZ72-mappedCitation-17403780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403780 |
| http://purl.uniprot.org/uniprot/#_Q7TP47-mappedCitation-17403780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403780 |
| http://purl.uniprot.org/uniprot/#_M0R735-mappedCitation-17403780 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17403780 |
| http://purl.uniprot.org/uniprot/M0R735 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17403780 |
| http://purl.uniprot.org/uniprot/Q7TP47 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/17403780 |