| http://purl.uniprot.org/citations/17403936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17403936 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17403936 | http://www.w3.org/2000/01/rdf-schema#comment | "Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma. The availability of free arachidonate in cells for subsequent eicosanoid biosynthesis is controlled by phospholipase A(2)s (PLA(2)s), most notably cytosolic PLA(2)-alpha. 10 secreted PLA(2)s (sPLA(2)s) have also been identified, but their function in eicosanoid generation is poorly understood. We investigated the role of group X sPLA(2) (sPLA(2)-X), the sPLA(2) with the highest in vitro cellular phospholipolysis activity, in acute and chronic mouse asthma models in vivo. The lungs of sPLA(2)-X(-/-) mice, compared with those of sPLA(2)-X(+/+) littermates, had significant reduction in ovalbumin-induced infiltration by CD4(+) and CD8(+) T cells and eosinophils, goblet cell metaplasia, smooth muscle cell layer thickening, subepithelial fibrosis, and levels of T helper type 2 cell cytokines and eicosanoids. These data direct attention to sPLA(2)-X as a novel therapeutic target for asthma."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20070029"xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.org/dc/terms/identifier | "doi:10.1084/jem.20070029"xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Gelb M.H."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Gelb M.H."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Ye X."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Ye X."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Nevalainen T."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Nevalainen T."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Chi E.Y."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Chi E.Y."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Singer A.G."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Singer A.G."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Rudensky A.Y."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Rudensky A.Y."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Rubtsov Y.P."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Rubtsov Y.P."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Bollinger J.G."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Bollinger J.G."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Castelli L."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Castelli L."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Chiang G.K."xsd:string |
| http://purl.uniprot.org/citations/17403936 | http://purl.uniprot.org/core/author | "Chiang G.K."xsd:string |