| http://purl.uniprot.org/citations/17404231 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17404231 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutations in polycystin-2 (PC2) cause autosomal dominant polycystic kidney disease. A function for PC2 in the heart has not been described. Here, we show that PC2 coimmunoprecipitates with the cardiac ryanodine receptor (RyR2) from mouse heart. Biochemical assays showed that the N terminus of PC2 binds the RyR2, whereas the C terminus only binds to RyR2 in its open state. Lipid bilayer electrophysiological experiments indicated that the C terminus of PC2 functionally inhibited RyR2 channel activity in the presence of calcium (Ca(2+)). Pkd2(-/-) cardiomyocytes had a higher frequency of spontaneous Ca(2+) oscillations, reduced Ca(2+) release from the sarcoplasmic reticulum stores, and reduced Ca(2+) content compared with Pkd2(+/+) cardiomyocytes. In the presence of caffeine, Pkd2(-/-) cardiomyocytes exhibited decreased peak fluorescence, a slower rate of rise, and a longer duration of Ca(2+) transients compared with Pkd2(+/+). These data suggest that PC2 is important for regulation of RyR2 function and that loss of this regulation of RyR2, as occurs when PC2 is mutated, results in altered Ca(2+) signaling in the heart."xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0610324104"xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/author | "Tian X."xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/author | "Somlo S."xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/author | "Ehrlich B.E."xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/author | "Estrada M."xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/author | "Anyatonwu G.I."xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/pages | "6454-6459"xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/title | "Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2."xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17404231 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17404231 |
| http://purl.uniprot.org/citations/17404231 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17404231 |
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