| http://purl.uniprot.org/citations/1740433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1740433 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1740433 | http://www.w3.org/2000/01/rdf-schema#comment | "A novel serum amyloid A protein (SAA) has been identified as a normal apolipoprotein component of non-acute phase high density lipoprotein. This novel SAA has been designated "constitutive" SAA (C-SAA) to distinguish it from "acute phase" SAA (A-SAA). C-SAA was partially sequenced, and immunochemical analyses indicated that it constitutes a distinct subclass of apolipoproteins within the SAA superfamily. A C-SAA cDNA clone was isolated from a human liver library and sequenced. The clone predicts a pre-C-SAA molecule of 130 residues from which an 18-residue leader peptide is cleaved. The 112-residue mature molecule is 8 residues longer than human A-SAA; the size difference is due to the presence of an octapeptide between positions 70 and 77 that is not found in the corresponding region of human A-SAA. Paradoxically, octapeptides of similar composition are found at similar positions in the A-SAAs of a number of other species. The C-SAA octapeptide specifies the first two residues of a NSS tripeptide, the only potential N-linked glycosylation site in the molecule. Studies indicate that approximately 50% of these sites are glycosylated, thereby giving rise to two size classes, 14 and 19 kDa, of C-SAA in vivo. Human acute phase liver contains little C-SAA mRNA relative to the levels of A-SAA mRNA, and the treatment of PLC/PRF/5 hepatoma cells with monocyte-conditioned medium does not induce C-SAA mRNA concentrations to detectable levels, in contrast to the massive induction of A-SAA mRNA observed. C-SAA is therefore not a major acute phase reactant."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)50605-6"xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(19)50605-6"xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Lane W.S."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Lane W.S."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Lelias J.M."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Lelias J.M."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Steel D.M."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Steel D.M."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Whitehead A.S."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Whitehead A.S."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Rits M."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Rits M."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Debeer F.C."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Debeer F.C."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Debeer M.C."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/author | "Debeer M.C."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/pages | "3862-3867"xsd:string |
| http://purl.uniprot.org/citations/1740433 | http://purl.uniprot.org/core/pages | "3862-3867"xsd:string |