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| http://purl.uniprot.org/citations/17404512 | http://www.w3.org/2000/01/rdf-schema#comment | "The Notch receptor family and its ligands (Delta-like and Jagged) have been found deregulated in several human cancers. We and the Aster/Pear group recently identified c-myc as a direct transcriptional target gene of the Notch1 pathway in T cell acute lymphoblastic leukemia (T-ALL). Although the oncogenic roles of c-Myc and Notch1 are established, a direct link between Notch1 and c-Myc had not been demonstrated. Importantly, our work in mouse tal1 tumor cell lines revealed that leukemic growth/survival remains dependent on the Notch1-c-Myc pathway. Studies by the Efstratiadis group provide genetic evidence that the Notch1-c-Myc pathway also contributes to mouse mammary tumorigenesis. Taken together, these studies demonstrate that Notch1 mediates T cell and epithelial cell transformation at least in part by sustaining c-Myc lev."xsd:string |
| http://purl.uniprot.org/citations/17404512 | http://purl.org/dc/terms/identifier | "doi:10.4161/cc.6.8.4134"xsd:string |
| http://purl.uniprot.org/citations/17404512 | http://purl.uniprot.org/core/author | "Sharma V.M."xsd:string |
| http://purl.uniprot.org/citations/17404512 | http://purl.uniprot.org/core/author | "Kelliher M.A."xsd:string |
| http://purl.uniprot.org/citations/17404512 | http://purl.uniprot.org/core/author | "Draheim K.M."xsd:string |
| http://purl.uniprot.org/citations/17404512 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17404512 | http://purl.uniprot.org/core/name | "Cell Cycle"xsd:string |
| http://purl.uniprot.org/citations/17404512 | http://purl.uniprot.org/core/pages | "927-930"xsd:string |
| http://purl.uniprot.org/citations/17404512 | http://purl.uniprot.org/core/title | "The Notch1/c-Myc pathway in T cell leukemia."xsd:string |
| http://purl.uniprot.org/citations/17404512 | http://purl.uniprot.org/core/volume | "6"xsd:string |
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