| http://purl.uniprot.org/citations/17404621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17404621 | http://www.w3.org/2000/01/rdf-schema#comment | "Erythropoiesis is critically dependent on erythropoietin (EPO), a glycoprotein hormone that is regulated by hypoxia-inducible factor (HIF). Hepatocytes are the primary source of extrarenal EPO in the adult and express HIF-1 and HIF-2, whose roles in the hypoxic induction of EPO remain controversial. In order to define the role of HIF-1 and HIF-2 in the regulation of hepatic EPO expression, we have generated mice with conditional inactivation of Hif-1alpha and/or Hif-2alpha (Epas1) in hepatocytes. We have previously shown that inactivation of the von Hippel-Lindau tumor suppressor pVHL, which targets both HIFs for proteasomal degradation, results in increased hepatic Epo production and polycythemia independent of Hif-1alpha. Here we show that conditional inactivation of Hif-2alpha in pVHL-deficient mice suppressed hepatic Epo and the development of polycythemia. Furthermore, we found that physiological Epo expression in infant livers required Hif-2alpha but not Hif-1alpha and that the hypoxic induction of liver Epo in anemic adults was Hif-2alpha dependent. Since other Hif target genes such phosphoglycerate kinase 1 (Pgk) were Hif-1alpha dependent, we provide genetic evidence that HIF-1 and HIF-2 have distinct roles in the regulation of hypoxia-inducible genes and that EPO is preferentially regulated by HIF-2 in the liver."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci30117"xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Liu Q."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Johnson R.S."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Simon M.C."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Keith B."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Haase V.H."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Biju M.P."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Unger T.L."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Rankin E.B."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/author | "Rha J."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/pages | "1068-1077"xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/title | "Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo."xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://purl.uniprot.org/core/volume | "117"xsd:string |
| http://purl.uniprot.org/citations/17404621 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17404621 |
| http://purl.uniprot.org/citations/17404621 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17404621 |
| http://purl.uniprot.org/uniprot/P97481#attribution-D8146E070059CEAF8BED3750DE78BDAE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17404621 |
| http://purl.uniprot.org/uniprot/P97481#attribution-EC0556C68806D0A55F29A88EB17C11A0 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17404621 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1E9-mappedCitation-17404621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17404621 |
| http://purl.uniprot.org/uniprot/#_A0A0R4J1F0-mappedCitation-17404621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17404621 |
| http://purl.uniprot.org/uniprot/#_A0A0N4SW09-mappedCitation-17404621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17404621 |
| http://purl.uniprot.org/uniprot/#_Q0VED9-mappedCitation-17404621 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17404621 |