| http://purl.uniprot.org/citations/17406648 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17406648 | http://www.w3.org/2000/01/rdf-schema#comment | "Elevated platelet serotonin (5-hydroxytryptamine, 5-HT) is found in a subset of children with autism and in some of their first-degree relatives. Indices of the platelet serotonin system, including whole blood 5-HT, 5-HT binding affinity for the serotonin transporter (K(m)), 5-HT uptake (V(max)), and lysergic acid diethylamide (LSD) receptor binding, were previously studied in 24 first-degree relatives of probands with autism, half of whom were selected for elevated whole blood 5-HT levels. All subjects were then genotyped for selected polymorphisms at the SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 loci. Previous studies allowed an a priori prediction of SLC6A4 haplotypes that separated the subjects into three groups that showed significantly different 5-HT binding affinity (K(m), p=0.005) and 5-HT uptake rate (V(max), p=0.046). Genotypes at four individual polymorphisms in SLC6A4 were not associated with platelet 5-HT indices. Haplotypes at SLC6A4 and individual genotypes of polymorphisms at SLC6A4, HTR7, HTR2A, ITGB3, and TPH1 showed no significant association with whole blood 5-HT. Haplotype analysis of two polymorphisms in TPH1 revealed a nominally significant association with whole blood 5-HT (p=0.046). These initial studies of indices of the 5-HT system with several single-nucleotide polymorphisms at loci in this system generate hypotheses for testing in other samples."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.npp.1301406"xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/author | "Kim S.J."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/author | "Cook E.H. Jr."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/author | "Leventhal B.L."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/author | "Weiss L.A."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/author | "Cross S."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/author | "Sutcliffe J.S."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/author | "Delahanty R.J."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/author | "Veenstra-Vanderweele J."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/name | "Neuropsychopharmacology"xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/pages | "353-360"xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/title | "Molecular genetics of the platelet serotonin system in first-degree relatives of patients with autism."xsd:string |
| http://purl.uniprot.org/citations/17406648 | http://purl.uniprot.org/core/volume | "33"xsd:string |
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