| http://purl.uniprot.org/citations/17409189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17409189 | http://www.w3.org/2000/01/rdf-schema#comment | "Recognition of lysine-type peptidoglycan by peptidoglycan recognition protein (PGRP)-SA provokes the activation of the Toll and prophenoloxidase pathways. Here we reveal that a soluble fragment of lysine-type peptidoglycan, a long glycan chain with short stem peptides, is a potent activator of the Drosophila Toll pathway and the prophenoloxidase activation cascade in the beetle Tenebrio molitor. Using this peptidoglycan fragment, we present biochemical evidence that clustering of PGRP-SA molecules on the peptidoglycan is required for the activation of the prophenoloxidase cascade. We subsequently highlight that the lysozyme-mediated partial digestion of highly cross-linked lysine-type peptidoglycan dramatically increases the binding of PGRP-SA, presumably by inducing clustering of PGRP-SA, which then recruits the Gram-negative bacteria-binding protein 1 homologue and a modular serine protease containing low-density lipoprotein and complement control protein domains. The crucial role of lysozyme in the prophenoloxidase activation cascade is further confirmed in vivo by using a lysozyme inhibitor. Taken together, we propose a model whereby lysozyme presents a processed form of lysine-type peptidoglycan for clustering of PGRP-SA that recruits Gram-negative bacteria-binding protein 1 and the modular serine protease, which leads to the activation of both the Toll and prophenoloxidase pathways."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0610924104"xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Kim J.H."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Kim S.J."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Kim C.H."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Lee H.H."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Oh B.H."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Park J.W."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Lim J.H."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Lee B.L."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Ryu J.H."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Lee W.J."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Ha N.C."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Roh K.B."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/author | "Je B.R."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/pages | "6602-6607"xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/title | "Clustering of peptidoglycan recognition protein-SA is required for sensing lysine-type peptidoglycan in insects."xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/17409189 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17409189 |
| http://purl.uniprot.org/citations/17409189 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17409189 |
| http://purl.uniprot.org/uniprot/Q9VYX7#attribution-926B61F7ADEE88AC1285EBE9C21677B2 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/17409189 |
| http://purl.uniprot.org/uniprot/#_P41964-mappedCitation-17409189 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17409189 |