| http://purl.uniprot.org/citations/17409267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17409267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17409267 | http://www.w3.org/2000/01/rdf-schema#comment | "Here we report the identification of a novel human leukocyte antigen (HLA)-B44-restricted minor histocompatibility antigen (mHA) with expression limited to hematopoietic cells. cDNA expression cloning studies demonstrated that the cytotoxic T lymphocyte (CTL) epitope of interest was encoded by a novel allelic splice variant of HMSD, hereafter designated as HMSD-v. The immunogenicity of the epitope was generated by differential protein expression due to alternative splicing, which was completely controlled by 1 intronic single-nucleotide polymorphism located in the consensus 5' splice site adjacent to an exon. Both HMSD-v and HMSD transcripts were selectively expressed at higher levels in mature dendritic cells and primary leukemia cells, especially those of myeloid lineage. Engraftment of mHA(+) myeloid leukemia stem cells in nonobese diabetic/severe combined immunodeficient (NOD/SCID)/gammac(null) mice was completely inhibited by in vitro preincubation with the mHA-specific CTL clone, suggesting that this mHA is expressed on leukemic stem cells. The patient from whom the CTL clone was isolated demonstrated a significant increase of the mHA-specific T cells in posttransplantation peripheral blood, whereas mHA-specific T cells were undetectable in pretransplantation peripheral blood and in peripheral blood from his donor. These findings suggest that the HMSD-v-encoded mHA (designated ACC-6) could serve as a target antigen for immunotherapy against hematologic malignancies."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-02-075911"xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2007-02-075911"xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Inoko H."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Inoko H."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Miyazaki M."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Miyazaki M."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Miyamura K."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Miyamura K."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Takahashi T."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Ogawa S."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Kuzushima K."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Kuzushima K."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Morishima S."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Morishima S."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Oka A."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Oka A."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Kawase T."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Kawase T."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Tsujimura A."xsd:string |
| http://purl.uniprot.org/citations/17409267 | http://purl.uniprot.org/core/author | "Tsujimura A."xsd:string |