| http://purl.uniprot.org/citations/17409409 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17409409 | http://www.w3.org/2000/01/rdf-schema#comment | "High-risk susceptibility genes explain <40% of the excess risk of familial ovarian cancer. Therefore, other ovarian cancer susceptibility genes are likely to exist. We have used a single nucleotide polymorphism (SNP)-tagging approach to evaluate common variants in 13 genes involved in cell cycle control-CCND1, CCND2, CCND3, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, and CDKN2D-and risk of invasive epithelial ovarian cancer. We used a two-stage, multicenter, case-control study. In stage 1, 88 SNPs that tag common variation in these genes were genotyped in three studies from the United Kingdom, United States, and Denmark ( approximately 1,500 cases and 2,500 controls). Genotype frequencies in cases and controls were compared using logistic regression. In stage 2, eight other studies from Australia, Poland, and the United States ( approximately 2,000 cases and approximately 3,200 controls) were genotyped for the five most significant SNPs from stage 1. No SNP was significant in the stage 2 data alone. Using the combined stages 1 and 2 data set, CDKN2A rs3731257 and CDKN1B rs2066827 were associated with disease risk (unadjusted P trend = 0.008 and 0.036, respectively), but these were not significant after adjusting for multiple testing. Carrying the minor allele of these SNPs was found to be associated with reduced risk [OR, 0.91 (0.85-0.98) for rs3731257; and OR, 0.93 (0.87-0.995) for rs2066827]. In conclusion, we have found evidence that a single tagged SNP in both the CDKN2A and CDKN1B genes may be associated with reduced ovarian cancer risk. This study highlights the need for multicenter collaborations for genetic association studies."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-06-3261"xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Chenevix-Trench G."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Easton D.F."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Cunningham J.M."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Lissowska J."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Ponder B.A."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Beesley J."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Couch F.J."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Gayther S.A."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Iversen E.S."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Berchuck A."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Marks J.R."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Brinton L."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Garcia-Closas M."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Goode E.L."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Peplonska B."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Pharoah P.D."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Hogdall C."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Hogdall E."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Jacobs I."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Kjaer S.K."xsd:string |
| http://purl.uniprot.org/citations/17409409 | http://purl.uniprot.org/core/author | "Quaye L."xsd:string |