| http://purl.uniprot.org/citations/17410437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17410437 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study, we examined the role of c-kit receptor (KIT) signal transduction on the proliferation and invasion of colorectal cancer cells. We found that c-kit was expressed in 2 colorectal cancer cell lines as determined by RT-PCR, Western blot, and flow cytometry. In KIT-positive lines, KIT was activated by stem cell factor (SCF). SCF enhanced cellular proliferation of positive lines as demonstrated by the WST-1 proliferation assay. Furthermore, SCF enhanced the invasive ability of KIT-positive cell lines. SCF stimulation upregulated p44/42 mitogen-activated protein kinase (MAPK) and Akt as shown by Western blot. We examined the roles played by p44/42 MAPK and phosphatidylinositol 3-kinase (PI3K)/Akt pathways in proliferation and invasion. PI3K/Akt activity strongly correlated with proliferation and invasion and p44/42 MAPK was correlated with only invasion. In conclusion, the SCF-enhanced proliferation and invasion of KIT-positive colorectal cancer cells is achieved mainly through the PI3K/Akt pathway."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10620-007-9759-7"xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Okada Y."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Sato M."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Takeyama H."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Takahashi H."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Yasuda A."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Matsuo Y."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Funahashi H."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Ochi N."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Sawai H."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/author | "Manabe T."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/name | "Dig Dis Sci"xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/pages | "2292-2300"xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/title | "Stem cell factor/c-kit receptor signaling enhances the proliferation and invasion of colorectal cancer cells through the PI3K/Akt pathway."xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://purl.uniprot.org/core/volume | "52"xsd:string |
| http://purl.uniprot.org/citations/17410437 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17410437 |
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| http://purl.uniprot.org/uniprot/#_Q24M88-mappedCitation-17410437 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17410437 |