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http://purl.uniprot.org/citations/17412364http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17412364http://www.w3.org/2000/01/rdf-schema#comment"

Background

The association between susceptibility to multiple sclerosis (MS) and HLA-DRB1*15 has been reported in various European populations.

Objective

To investigate the relationship between MS, HLA-DRB1*15 and other DRB1 alleles in a Portuguese population and their association with clinical course of MS.

Methods

The HLA-DRB1 alleles were analyzed by PCR-SSP in 248 MS patients and 282 healthy controls. In order to relate HLA-DRB1 alleles to disease aggressiveness, patients with relapsing remitting MS and secondary progressive MS were subdivided into 3 groups: 'benign' MS patients who maintain an Extended Disability Status Scale (EDSS) score of 3 after the same period and 'aggressive' MS those with EDSS>or=6 within 15 years of disease onset.

Results

As expected, a higher frequency of HLA-DRB1*15 was found in MS patients (29.8% vs 19.9%, odds ratio (OR)=1.72, 95% CI=1.15-2.56, p=0.008). The HLA-DRB1*03 allele was positively associated with MS in the overall patient population (22.6% vs 15.6%, OR=1.58, 95% CI=1.02-2.45). Concerning disease aggressiveness, HLA-DRB1*15 occurred more frequently in the group with benign disease (42.6% vs 19.9%, OR=2.99, 95% CI=1.56-5.72) and in the group with non-benign disease (34.1% vs 19.9%, OR=2.09, 95% CI=1.05-4.16) compared with controls. When time to reach an EDSS=3 or EDSS=6 was considered as end point, HLA-DRB1*15 negative patients were found to have a worse prognosis.

Conclusions

In this population of Portuguese MS patients, the HLA-DRB1*15 allele is established as a genetic marker for susceptibility to MS and is also associated with a better outcome."xsd:string
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http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Silva A.M."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Carvalho C."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Pereira C."xsd:string
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http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Monteiro L."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Mendonca D."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Costa P.P."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Marta M."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Couto A.R."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Armas J.B."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Bettencourt A."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Freijo M."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/author"Leite M.I."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/date"2007"xsd:gYear
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/name"J Neurol Sci"xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/pages"69-74"xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/title"The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population."xsd:string
http://purl.uniprot.org/citations/17412364http://purl.uniprot.org/core/volume"258"xsd:string
http://purl.uniprot.org/citations/17412364http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/17412364
http://purl.uniprot.org/citations/17412364http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/17412364
http://purl.uniprot.org/uniprot/#_A0A0A7C3H3-mappedCitation-17412364http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17412364
http://purl.uniprot.org/uniprot/#_A0A0A7C3I1-mappedCitation-17412364http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/17412364
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