| http://purl.uniprot.org/citations/17412961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17412961 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17412961 | http://www.w3.org/2000/01/rdf-schema#comment | "Although highly homologous, the spliceosomal hPrp31 and the nucleolar Nop56 and Nop58 (Nop56/58) proteins recognize different ribonucleoprotein (RNP) particles. hPrp31 interacts with complexes containing the 15.5K protein and U4 or U4atac small nuclear RNA (snRNA), whereas Nop56/58 associate with 15.5K-box C/D small nucleolar RNA complexes. We present structural and biochemical analyses of hPrp31-15.5K-U4 snRNA complexes that show how the conserved Nop domain in hPrp31 maintains high RNP binding selectivity despite relaxed RNA sequence requirements. The Nop domain is a genuine RNP binding module, exhibiting RNA and protein binding surfaces. Yeast two-hybrid analyses suggest a link between retinitis pigmentosa and an aberrant hPrp31-hPrp6 interaction that blocks U4/U6-U5 tri-snRNP formation."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1137924"xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1137924"xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Li P."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Wahl M.C."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Carlomagno T."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Carlomagno T."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Luehrmann R."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Luehrmann R."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Dybkov O."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Dybkov O."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Hartmuth K."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Hartmuth K."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Nottrott S."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/author | "Nottrott S."xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/17412961 | http://purl.uniprot.org/core/name | "Science"xsd:string |