DESCRIBE <http://purl.uniprot.org/citations/17414215>

Subject	Predicate	Object
http://purl.uniprot.org/citations/17414215	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/17414215	http://www.w3.org/2000/01/rdf-schema#comment	" Purpose of review There is considerable interest in understanding the function and mechanism of calpains in platelet aggregation, spreading, and granular secretion pathways. Recent insights from the calpain-1 knockout platelets suggest a pivotal role of these cysteine proteases in the regulation of outside-in signaling, aggregation, and clot retraction. Recent findings The calpain-1 knockout mouse provided direct evidence for the role of calpain-1 in platelet aggregation and clot retraction. Reduced tyrosine phosphorylation of platelet proteins correlated with reduced platelet aggregation and clot retraction. Future investigations of the mechanism of platelet defects in calpain-1 null mice may unveil the physiological functions of this important and elusive protease in mammalian cells. Summary This review focuses on the role of calpains in platelets with a particular emphasis on recent findings in calpain-1 null platelets. Previous studies used synthetic inhibitors to study the role of calpains in platelet function yielding useful information about the identification of calpain substrates. The development of calpain-1 null mice demonstrated that calpain-1 plays an important function in the regulation of platelet aggregation and clot retraction. Since the combined deletion of calpain-1 and calpain-2 genes results in embryonic lethality, the calpain-1 null mouse remains the only experimental model available to study the physiological role of calpains in mammalian cells."xsd:string
http://purl.uniprot.org/citations/17414215	http://purl.org/dc/terms/identifier	"doi:10.1097/moh.0b013e3280ef68f8"xsd:string
http://purl.uniprot.org/citations/17414215	http://purl.uniprot.org/core/author	"Chishti A.H."xsd:string
http://purl.uniprot.org/citations/17414215	http://purl.uniprot.org/core/author	"Kuchay S.M."xsd:string
http://purl.uniprot.org/citations/17414215	http://purl.uniprot.org/core/date	"2007"xsd:gYear
http://purl.uniprot.org/citations/17414215	http://purl.uniprot.org/core/name	"Curr Opin Hematol"xsd:string
http://purl.uniprot.org/citations/17414215	http://purl.uniprot.org/core/pages	"249-254"xsd:string
http://purl.uniprot.org/citations/17414215	http://purl.uniprot.org/core/title	"Calpain-mediated regulation of platelet signaling pathways."xsd:string
http://purl.uniprot.org/citations/17414215	http://purl.uniprot.org/core/volume	"14"xsd:string
http://purl.uniprot.org/citations/17414215	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/17414215
http://purl.uniprot.org/citations/17414215	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/17414215
http://purl.uniprot.org/uniprot/#_O35350-mappedCitation-17414215	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/#_Q3TI07-mappedCitation-17414215	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/#_Q3UDG8-mappedCitation-17414215	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/#_Q80Y25-mappedCitation-17414215	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/#_Q3TB79-mappedCitation-17414215	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/#_Q3UF24-mappedCitation-17414215	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/#_Q8C2J1-mappedCitation-17414215	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/Q3UDG8	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/O35350	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/Q3TI07	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/Q80Y25	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/Q3TB79	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17414215
http://purl.uniprot.org/uniprot/Q8C2J1	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/17414215