| http://purl.uniprot.org/citations/17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17417626 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondria are critically involved in necrotic cell death induced by Ca(2+) overload, hypoxia and oxidative damage. The mitochondrial permeability transition (MPT) pore - a protein complex that spans both the outer and inner mitochondrial membranes - is considered the mediator of this event and has been hypothesized to minimally consist of the voltage-dependent anion channel (Vdac) in the outer membrane, the adenine-nucleotide translocase (Ant) in the inner membrane and cyclophilin-D in the matrix. Here, we report the effects of deletion of the three mammalian Vdac genes on mitochondrial-dependent cell death. Mitochondria from Vdac1-, Vdac3-, and Vdac1-Vdac3-null mice exhibited a Ca(2+)- and oxidative stress-induced MPT that was indistinguishable from wild-type mitochondria. Similarly, Ca(2+)- and oxidative-stress-induced MPT and cell death was unaltered, or even exacerbated, in fibroblasts lacking Vdac1, Vdac2, Vdac3, Vdac1-Vdac3 and Vdac1-Vdac2-Vdac3. Wild-type and Vdac-deficient mitochondria and cells also exhibited equivalent cytochrome c release, caspase cleavage and cell death in response to the pro-death Bcl-2 family members Bax and Bid. These results indicate that Vdacs are dispensable for both MPT and Bcl-2 family member-driven cell death."xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncb1575"xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/author | "Molkentin J.D."xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/author | "Craigen W.J."xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/author | "Baines C.P."xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/author | "Kaiser R.A."xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/author | "Sheiko T."xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/date | "2007"xsd:gYear |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/name | "Nat Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/pages | "550-555"xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/title | "Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death."xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/17417626 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/17417626 |
| http://purl.uniprot.org/citations/17417626 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/17417626 |
| http://purl.uniprot.org/uniprot/#_A0A165ELP6-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT35-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT81-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GTA4-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_F7CUQ1-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS13-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_A0A286YCR8-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_A0A494BB74-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |
| http://purl.uniprot.org/uniprot/#_D3YUN8-mappedCitation-17417626 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/17417626 |