| http://purl.uniprot.org/citations/17418785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17418785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/17418785 | http://www.w3.org/2000/01/rdf-schema#comment | "Caspases are intracellular proteases that cleave substrates involved in apoptosis or inflammation. In C. elegans, a paradigm for caspase regulation exists in which caspase CED-3 is activated by nucleotide-binding protein CED-4, which is suppressed by Bcl-2-family protein CED-9. We have identified a mammalian analog of this caspase-regulatory system in the NLR-family protein NALP1, a nucleotide-dependent activator of cytokine-processing protease caspase-1, which responds to bacterial ligand muramyl-dipeptide (MDP). Antiapoptotic proteins Bcl-2 and Bcl-X(L) bind and suppress NALP1, reducing caspase-1 activation and interleukin-1beta (IL-1beta) production. When exposed to MDP, Bcl-2-deficient macrophages exhibit more caspase-1 processing and IL-1beta production, whereas Bcl-2-overexpressing macrophages demonstrate less caspase-1 processing and IL-1beta production. The findings reveal an interaction of host defense and apoptosis machinery."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.01.045"xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2007.01.045"xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Matsuzawa S."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Matsuzawa S."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Xu C."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Osterman A."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Osterman A."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Faustin B."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Faustin B."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Reed J.C."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Reed J.C."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Terskikh A.V."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Terskikh A.V."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Zhai D."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Zhai D."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Bailly-Maitre B."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Bailly-Maitre B."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Bruey J.M."xsd:string |
| http://purl.uniprot.org/citations/17418785 | http://purl.uniprot.org/core/author | "Bruey J.M."xsd:string |